Obesity and androgens: facts and perspectives

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Obesity and androgens: facts and perspectives Renato Pasquali, M.D. Fertility and Sterility Volume 85, Issue 5, Pages 1319-1340 (May 2006) DOI: 10.1016/j.fertnstert.2005.10.054 Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Schematic view of the interaction between androgens and obesity and its different phenotypes. Pasquali. Obesity and androgens. Fertil Steril 2006. Fertility and Sterility 2006 85, 1319-1340DOI: (10.1016/j.fertnstert.2005.10.054) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Luteinizing hormone (LH) pituitary secretion is related to body mass index in men. Mean diurnal levels = integrated (diurnal) levels measured as the mean of the values obtained over 12 h; Σ pulse amplitude = sum of all diurnal pulse amplitudes of LH. From Vermeulen et al. (19), with permission of the editor. Pasquali. Obesity and androgens. Fertil Steril 2006. Fertility and Sterility 2006 85, 1319-1340DOI: (10.1016/j.fertnstert.2005.10.054) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 The relationship between free androgen index (FAI) and the hypothalamic-pituitary-adrenal axis (evaluated by the cortisol response to combined corticotropin-releasing hormone and arginine vasopressin stimulation) in obese men (A) and obese women (B). (from reference 63, with permission of the editor.) Pasquali. Obesity and androgens. Fertil Steril 2006. Fertility and Sterility 2006 85, 1319-1340DOI: (10.1016/j.fertnstert.2005.10.054) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 4 Relationship between leptin and basal (right) and hCG-stimulated (left) testosterone (expressed as the ratio between 17-hydroxyprogesterone (17-OHP) and testosterone (T) (A, left) and the ratio between E2 and T (B, left) in overweight (BMI<30) and obese (BMI 30–40 and BMI >40) males. From Isidori et al. (90), with permission of the editor. Pasquali. Obesity and androgens. Fertil Steril 2006. Fertility and Sterility 2006 85, 1319-1340DOI: (10.1016/j.fertnstert.2005.10.054) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions