Selfish Stem Cells Compete with Each Other Yukiko M. Yamashita  Cell Stem Cell  Volume 2, Issue 1, Pages 3-4 (January 2008) DOI: 10.1016/j.stem.2007.12.008 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Models for Stem Cell Competition (A) The bam/bgcn mutant GSCs (orange) “push” wild-type GSCs (green) out of the niche (blue) due to their higher expression of E-cadherin (red). (B) The bam/bgcn mutant GSCs generate germline cell tumors, which result in a larger pool of GSCs/cystoblasts/cystocytes (pink) than that generated by wild-type GSCs (light green). As a result, they are more likely to give rise to GSCs via dedifferentiation during “natural turnover” of GSCs. (C) GSCs with higher E-cadherin (red) levels may have a similar advantage during dedifferentiation. Cell Stem Cell 2008 2, 3-4DOI: (10.1016/j.stem.2007.12.008) Copyright © 2008 Elsevier Inc. Terms and Conditions