Urinary cell casts, lymph node weights and proteinuria in the lpr-water, lpr-CU and lpr-TU groups of mice. Urinary cell casts, lymph node weights and proteinuria.

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Urinary cell casts, lymph node weights and proteinuria in the lpr-water, lpr-CU and lpr-TU groups of mice. Urinary cell casts, lymph node weights and proteinuria in the lpr-water, lpr-CU and lpr-TU groups of mice. (a) Urinary cell casts in the lpr-water group. (A–D) Red or white cell casts in four individual mice belonging to the lpr-water group at week 14. None of the mice in the lpr-CU or lpr-TU group had urinary cell casts at week 14; (bA) average lymph node weights in the lpr-water, lpr-CU and lpr-TU groups of mice. Average lymph node weights: lpr-water group= 2606 mg; lpr-CU= 743 mg; lpr-TU=385 mg. *p=0.03, lpr-water group versus lpr-CU group; **p=0.02, lpr-water group versus lpr-TU group (Mann–Whitney U test). Values are given as means±SE for each group. Statistical analyses were done by Mann–Whitney U test and the p-value was arrived at to assess the statistical significance of the changes observed. p<0.05 was considered to be significant; (bB) Weight of lymph nodes at death for the lpr-water, lpr-CU and lpr-TU groups of mice; (c) proteinuria in the MRL-lpr/lpr and MRL-MpJ mice provided with water, CU or TU analysed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS PAGE) (third urine collection; week 11). In total, 20 µL urine from each mouse was electrophoresed on 4–20% SDS-PAGE gels and stained with Coomassie brilliant blue. Lanes 1–6: MpJ-water group; lanes 7–12: MpJ-CU group; lanes 13–18: MpJ-TU group; lanes 19–24: lpr-water group; lanes 25–29: lpr-CU group; lanes 31–36: lpr-TU group. Increased protein excretion can be seen in the lpr-water group compared with the lpr-CU, lpr-TU and control MpJ mice. CU, curcumin; TU, turmeric. Biji T Kurien et al. Lupus Sci Med 2015;2:e000114 ©2015 by Lupus Foundation of America