HIV Broadly Neutralizing Antibodies: Taking Good Care Of The 98% Devin Sok, Dennis R. Burton  Immunity  Volume 45, Issue 5, Pages 958-960 (November 2016) DOI: 10.1016/j.immuni.2016.10.033 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Breadth and Potency of N6 Relative to a Number of Other Prototype bNAbs Broadly neutralizing antibodies (bNAbs) targeting different sites of vulnerability on HIV Env are plotted according to their percent coverage and potency. Coverage is defined as the percent of cross-clade viruses neutralized in a large virus panel, and potency is defined as the median IC50 of neutralized viruses in μg/mL. The main bNAb epitopes are indicated by color, as shown in the figure key. Note that different panels of viruses have been used for many of the antibodies, so comparisons are approximate. For example, PGDM1400 was reported to have 83% breadth and a median IC50 of 0.003 μg/mL (Sok et al., 2014), but measured on the panel in Huang et al., the breadth was reported to be 78% with a median IC50 of 0.008 μg/mL. See Burton and Hangartner (2016) for further details on this type of plot. Immunity 2016 45, 958-960DOI: (10.1016/j.immuni.2016.10.033) Copyright © 2016 Elsevier Inc. Terms and Conditions