The potential clinical utility of serum α-protryptase levels

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Presentation transcript:

The potential clinical utility of serum α-protryptase levels Sukanya Kanthawatana, MD, PhD, Katherine Carias, MD, Rand Arnaout, MD, Jiang Hu, Anne-Marie A. Irani, MD, Lawrence B. Schwartz, MD, PhD Journal of Allergy and Clinical Immunology Volume 103, Issue 6, Pages 1092-1099 (June 1999) DOI: 10.1016/S0091-6749(99)70184-3 Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 1 Suspected mastocytosis. Total tryptase values (ng/mL) and the total tryptase/β-tryptase ratios are shown for subjects with suspected mastocytosis who were subdivided into those with positive biopsy results (biopsy+), those with negative biopsy results (biopsy–), and those not undergoing biopsy. Filled symbols represent those samples in which β-tryptase was 1 ng/mL or less, giving a ratio that was numerically equivalent to the total tryptase value. Mastocytosis with an associated hematologic disorder (open squares), mastocytosis diagnosed by gastric biopsy alone (open traingles), and the sample corresponding to a negative skin biopsy alone (open inverted triangles) are shown as indicated. Box and whisker plots show median, 25th and 75th percentiles (rectangles), 10th and 90th percentiles (whiskers), and outliers (+). A horizontal dashed line is shown at the 20 ng/mL cutoff for total tryptase. Journal of Allergy and Clinical Immunology 1999 103, 1092-1099DOI: (10.1016/S0091-6749(99)70184-3) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 2 Follow-up tryptase values in suspected mastocytosis. Follow-up tryptase values were obtained in 8 subjects with suspected mastocytosis. Filled circles are total tryptase values; open circles are total tryptase/β-tryptase ratios. *Acutely symptomatic. Journal of Allergy and Clinical Immunology 1999 103, 1092-1099DOI: (10.1016/S0091-6749(99)70184-3) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 3 Suspected anaphylaxis. Total tryptase values (ng/mL) and the total tryptase/β-tryptase ratios are shown for subjects with suspected anaphylaxis who were subdivided into living and deceased groups. Closed symbols represent those samples in which β-tryptase was 1 ng/mL or less, giving a ratio that was numerically equivalent to the total tryptase value. Box and whisker plots are as described in Fig 1. A horizontal dashed line is shown at 20 ng/mL, and a dotted line is shown at 10 ng/mL. Journal of Allergy and Clinical Immunology 1999 103, 1092-1099DOI: (10.1016/S0091-6749(99)70184-3) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 4 Follow-up tryptase values in suspected anaphylaxis. Follow-up tryptase values were obtained in 5 subjects with suspected anaphylaxis. Filled circles are total tryptase values; open circles are total tryptase/β-tryptase ratios. A horizontal dashed line is shown at 20 ng/mL, and a dotted line is shown at 10 ng/mL. Journal of Allergy and Clinical Immunology 1999 103, 1092-1099DOI: (10.1016/S0091-6749(99)70184-3) Copyright © 1999 Mosby, Inc. Terms and Conditions