Fig. 1 AVPR1A is regulated by the AR coactivator VAV3 and AR-V7 and is increased in advanced human PC. AVPR1A is regulated by the AR coactivator VAV3 and.

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Fig. 1 AVPR1A is regulated by the AR coactivator VAV3 and AR-V7 and is increased in advanced human PC. AVPR1A is regulated by the AR coactivator VAV3 and AR-V7 and is increased in advanced human PC. (A) Gene expression profiling revealed that doxycycline-induced depletion of AR-V7 or VAV3 in 22Rv1 cells resulted in decreased AVPR1A mRNA (Student’s t test, P < 0.05). (B) VAV3 or AR-V7 was stably depleted by shRNA in 22Rv1 cells analyzed by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) for AVPR1A mRNA (Student’s t test, **P < 0.01). One experiment was done in triplicate. (C) AVPR1A mRNA was quantified in VCaP xenograft tumors with (VAV3) or without (GFP) VAV3 overexpression harvested before castration (androgen dependent) or at the end of the study (CRPC). The following xenograft tissues were evaluated: androgen-dependent/GFP (n = 3), androgen-dependent/VAV3 (n = 3), CRPC/GFP (n = 5), and CRPC/VAV3 (n = 7) [one-way analysis of variance (ANOVA) with Bonferroni correction, **P < 0.01]. (D) Tamura PC datasets were obtained and analyzed using National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) (24) to show AVPR1A mRNA in human hormone-sensitive specimens versus CRPC samples (**P < 0.01). (E) Chandran PC datasets were obtained and analyzed using NCBI GEO (25) to show AVPR1A mRNA in human primary site (prostate) specimens versus metastatic samples (**P < 0.01). (F) AVPR1A gene is amplified in 21% of metastatic CRPC tumors in the Beltran et al. (23) human CRPC dataset (81 patients with metastatic CRPC). Data were retrieved and analyzed using the cBioPortal (**P < 0.01) (29, 30). Ning Zhao et al., Sci Transl Med 2019;11:eaaw4636 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works