Fig. 1. Ca2+-dependent spike frequency adaptation and adaptation index Fig. 1. Ca2+-dependent spike frequency adaptation and adaptation index. (A) TC neuron with a depolarizing current injection to induce tonic firing in 2.4 mM Ca2+ buffer displays the prolongation of inter-spike intervals (ISI). Adaptation index can be obtained from the ration of 1st ISI over nth ISI. (B) Replacement of extracellular buffer to Ca2+-free buffer abolishes the spike-frequency adaptation. Fig. 1. Ca2+-dependent spike frequency adaptation and adaptation index. (A) TC neuron with a depolarizing current injection to induce tonic firing in 2.4 mM Ca2+ buffer displays the prolongation of inter-spike intervals (ISI). Adaptation index can be obtained from the ration of 1st ISI over nth ISI. (B) Replacement of extracellular buffer to… Exp Neurobiol. 2017 Aug;26(4):179-185. https://doi.org/10.5607/en.2017.26.4.179