Peter M. Elias Journal of Investigative Dermatology

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The Epidermal Permeability Barrier: From the Early Days at Harvard to Emerging Concepts Peter M. Elias Journal of Investigative Dermatology Volume 122, Issue 2, Pages xxxvi-xxxix (February 2004) DOI: 10.1046/j.0022-202X.2004.22233.x Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Endogenous pathways of SC acidification: regulated functions.. Journal of Investigative Dermatology 2004 122, xxxvi-xxxixDOI: (10.1046/j.0022-202X.2004.22233.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Proposed pH-dependent role of different proteases in desquamation.. Journal of Investigative Dermatology 2004 122, xxxvi-xxxixDOI: (10.1046/j.0022-202X.2004.22233.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Functions potentially impacted by filaggrin metabolism in SC.. Journal of Investigative Dermatology 2004 122, xxxvi-xxxixDOI: (10.1046/j.0022-202X.2004.22233.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Cutaneous stress test: applications.. Journal of Investigative Dermatology 2004 122, xxxvi-xxxixDOI: (10.1046/j.0022-202X.2004.22233.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 5 Cutaneous stress test reveals additional risk factors.. Journal of Investigative Dermatology 2004 122, xxxvi-xxxixDOI: (10.1046/j.0022-202X.2004.22233.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions