Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases Xingnan Li, PhD, Elizabeth J. Ampleford,

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Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases Xingnan Li, PhD, Elizabeth J. Ampleford, PhD, Timothy D. Howard, PhD, Wendy C. Moore, MD, Dara G. Torgerson, PhD, Huashi Li, MS, William W. Busse, MD, Mario Castro, MD, Serpil C. Erzurum, MD, Elliot Israel, MD, Dan L. Nicolae, PhD, Carole Ober, PhD, Sally E. Wenzel, MD, Gregory A. Hawkins, PhD, Eugene R. Bleecker, MD, Deborah A. Meyers, PhD Journal of Allergy and Clinical Immunology Volume 130, Issue 4, Pages 861-868.e7 (October 2012) DOI: 10.1016/j.jaci.2012.04.041 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Genome-wide association of 474,271 SNPs in 813 SARP/CSGA/CAG cases, 553 SARP/CSGA/CAG control subjects, and 1,011 Illumina control subjects. The color scale of the x-axis represents chromosomes. Negative log-transformed genomic control–adjusted P values are shown on the y-axis. Journal of Allergy and Clinical Immunology 2012 130, 861-868.e7DOI: (10.1016/j.jaci.2012.04.041) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Comparison of GWASs of asthma and autoimmune diseases. Red upward-pointing arrows indicate higher gene expression levels or protein activities. Green downward-pointing arrows indicate the lower gene expression levels or protein activities. Question marks indicate the lack of available experimental evidence. Journal of Allergy and Clinical Immunology 2012 130, 861-868.e7DOI: (10.1016/j.jaci.2012.04.041) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 QQ-plot of the GWAS of asthma in SARP/CSGA/CAG. Negative log-transformed expected P values are shown on the x-axis. Negative log-transformed observed P values are shown on the y-axis. Journal of Allergy and Clinical Immunology 2012 130, 861-868.e7DOI: (10.1016/j.jaci.2012.04.041) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 LD plot of 27 SNPs in TNIP1 regions. The r2 color scheme was used and labeled. 95% CIs on D′ were used to set up blocks. Journal of Allergy and Clinical Immunology 2012 130, 861-868.e7DOI: (10.1016/j.jaci.2012.04.041) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions