Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study Gwinnett Ladson,

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Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study Gwinnett Ladson, M.D., William C. Dodson, M.D., Stephanie D. Sweet, M.D., Anthony E. Archibong, Ph.D., Allen R. Kunselman, M.A., Laurence M. Demers, Ph.D., Peter A. Lee, M.D., Ph.D., Nancy I. Williams, Sc.D., Ponjola Coney, M.D., Richard S. Legro, M.D. Fertility and Sterility Volume 95, Issue 8, Pages 2595-2598.e6 (June 2011) DOI: 10.1016/j.fertnstert.2011.05.048 Copyright © 2011 Terms and Conditions

Figure 1 (A) Changes in total serum testosterone, (B) Free Androgen Index (FAI), (C) acne lesion count, and (D) weight over 6 months by treatment arm. Metformin = combined metformin and lifestyle; Placebo = lifestyle and metformin. ∗P<.05 for a within-group change from baseline, † P<.05 for a between-group comparison at a given month. Fertility and Sterility 2011 95, 2595-2598.e6DOI: (10.1016/j.fertnstert.2011.05.048) Copyright © 2011 Terms and Conditions

Supplemental Figure 1 Flow chart of study participants in the trial. Fertility and Sterility 2011 95, 2595-2598.e6DOI: (10.1016/j.fertnstert.2011.05.048) Copyright © 2011 Terms and Conditions