NoCut: Cytokinesis in Check

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NoCut: Cytokinesis in Check Kerry Bloom Cell Volume 125, Issue 1, Pages 17-18 (April 2006) DOI: 10.1016/j.cell.2006.03.016 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Cytokinesis Gone Awry The Lac repressor, a DNA binding protein, fused to GFP binds to lac operator sequences integrated into the yeast genome. This fluorescently labels a region of the yeast DNA (visualized as a green spot) that can be monitored using timelapse video microscopy. The outlined cell contains a lagging dicentric chromosome that fails to segregate into both mother (M) and daughter (D) cells (panel 1, leftmost panel). Upon cell separation (noted by change in position of the daughter and mother cell between the first and second panel), DNA left in the cytokinesis furrow is extruded from the cell (panel 2) and released from these cells over time (panels 3 and 4). Images courtesy of Doug Thrower and Kerry Bloom. Cell 2006 125, 17-18DOI: (10.1016/j.cell.2006.03.016) Copyright © 2006 Elsevier Inc. Terms and Conditions