Systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic sclerosis (SSc) cause immune-mediated.

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Presentation transcript:

Systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic sclerosis (SSc) cause immune-mediated damage to the heart, which may manifest as acute inflammation, fibrosis, valve disease, remodelling towards heart failure, endothelial and cardiomyocyte dysfunction or arrhythmias. Systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic sclerosis (SSc) cause immune-mediated damage to the heart, which may manifest as acute inflammation, fibrosis, valve disease, remodelling towards heart failure, endothelial and cardiomyocyte dysfunction or arrhythmias. To study selected or combined cardiac phenotypes, the research community benefits from a wide range of spontaneous, inducible and engineered mouse models, which allow mechanistic studies to improve our understanding and identify targets for new therapeutic approaches. IFN-γ, interferon gamma; ANAs, anti-nuclear antibodies; R-848, resiquimod; PD-1−/−, programmed cell death 1 knockout mice; TTP−/−, tristetraprolin knockout mice; Fra-2, fos-related antigen 2 transgenic mice. Chandan Sanghera et al. Dis. Model. Mech. 2019;12:dmm036947 © 2019. Published by The Company of Biologists Ltd