CD8α+, CD8α−, and MoDCs from NOD.hCD205 mice express hCD205.

Slides:

Advertisements

Similar presentations

Synergistic antitumor effect of anti-CD40/CpG and 14

Advertisements

MR1-TM inhibits the development of severe ATD and pSS in CD28−/− NOD

Volume 6, Issue 5, Pages (November 2009)

Type 17 immunity is increased in STAT1−/− mice.

PD-1 deficiency promotes the development of splenic GCs in male mice, and MR1 dissolves GCs in both genders. PD-1 deficiency promotes the development of.

MP cells are generated from naïve cells in the periphery.

Volume 20, Issue 3, Pages (July 2017)

Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG mice. Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG.

Depo-Provera altered the expression of cell surface markers associated with HIV susceptibility. Depo-Provera altered the expression of cell surface markers.

MR1 inhibits anti-MTg autoantibody responses in CD28−/− NOD

Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. Changes in splenic CD4+ and CD8+ T cell subsets.

Loss of Runx2 in the T cell compartment leads to a defect in the number of CD8+ memory precursor T cells during LCMV–Armstrong infection. Loss of Runx2.

Smaller T cell zone FRC areas in aged spleens.

A single DNA vaccination of C57BL/6 mice induced Ab responses of IgG1 and/or IgG2c subclass. A single DNA vaccination of C57BL/6 mice induced Ab responses.

Increased chemokine content and leukocyte infiltrate in D6-negative tumors. Increased chemokine content and leukocyte infiltrate in D6-negative tumors.

DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate.

VLPs activate DCs and antigen-specific CD8+ T cells via the STING and cGAS pathway. VLPs activate DCs and antigen-specific CD8+ T cells via the STING and.

Altered cytokine production by Klrk1−/− NOD CTL

Fig. 3 In situ vaccination with CpG and anti-OX40 is therapeutic in a spontaneous tumor model. In situ vaccination with CpG and anti-OX40 is therapeutic.

CD169+ macrophages mediate Lm translocation to the splenic T cell zones. CD169+ macrophages mediate Lm translocation to the splenic T cell zones. (A) Confocal.

Immune cell populations, activation, and NKG2D and H60a expression in the spleen of untreated and antibiotic-treated Klrk1+/+ and Klrk1−/− NOD mice. Immune.

Loss of DGKζ and Cbl-b results in a greater percentage of splenic CD8+ T cells with an activated phenotype. Loss of DGKζ and Cbl-b results in a greater.

IFN-γ induces TNF family ligand protein expression in vitro and in vivo. IFN-γ induces TNF family ligand protein expression in vitro and in vivo. (A and.

Mohamed A. Saleh et al. BTS 2016;1:

Inflammatory APC show highest expression of TNF superfamily ligands in the lung after LCMV infection. Inflammatory APC show highest expression of TNF superfamily.

NKG2D-dependent NK cell function in CD11c-Rae1 mice

Peptide concentration controls digital NFAT1 nuclear translocation kinetics in a responder fraction of stimulated naive OT-I cells. Peptide concentration.

Role of TLR signaling in hY4-induced changes and effects of TLR inhibition. Role of TLR signaling in hY4-induced changes and effects of TLR inhibition.

CD8+ T cells were immunomodulated and required for the efficacy of anti–4-1BB/anti–PD-1 combination treatment. CD8+ T cells were immunomodulated and required.

IL-27 contributes to IR expression by lung T cells during toxoplasmosis. IL-27 contributes to IR expression by lung T cells during toxoplasmosis. (A) Il27p28-GFP.

cMΦ develop into 4 subpopulations after birth.

Differential expression of TRM markers by donor- and recipient-derived T cells with time. Differential expression of TRM markers by donor- and recipient-derived.

The mucosal environment regulates CD160 expression on IELs

The microbiota downregulate CD160 expression on IELs

PD-L1 expression is maintained on NCMs under inflammatory conditions and PD-L1+NCMs are found in TLOs. PD-L1 expression is maintained on NCMs under inflammatory.

AhR activation reduces lung DC gene and surface expression of DC-SIGN.

APCs from hypertensive mice present antigens more efficiently.

TSG-6 suppressed APC activation in vitro and in vivo.

GLUT4 LXRE is required for downregulation of adipose GLUT4 mRNA during fasting and diet-induced obesity. GLUT4 LXRE is required for downregulation of adipose.

SYK activity is required for anti-IgM–induced DNA synthesis.

SYK activity is required for anti-IgM–induced CD86 expression.

B cell development in wild-type and Syk-AQL mice.

NOD.hCD205 mice are susceptible to T1D.

Slc7a5 expression in preosteoclasts is reduced in ovariectomized mice.

Fig. 4. Genetically engineered PD-L1

Phenotypic characterization of splenic and islet-infiltrating B-cells in 12-week-old NOD female mice. Phenotypic characterization of splenic and islet-infiltrating.

LG NK cells appear to be conventional in phenotype.

Members of IL-1 family of cytokines favor the generation of IL-3–secreting CD4+ T cells in vitro. Members of IL-1 family of cytokines favor the generation.

Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice. Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice.

CD25 surface expression and TCR signal strength predict T helper differentiation and memory potential of early effector T cells in vivo. CD25 surface expression.

Loss of Tfh and GC B cells in 2KO-Bcl6TC mice.

Increased anti-DNA Abs in 2KO-Bcl6TC mice.

Overexpression of IL-27 upregulates expression of multiple IR by T cells in vivo. Overexpression of IL-27 upregulates expression of multiple IR by T cells.

CD11c+ DCs from NOD.hCD205 mice are able to process and present Ag to diabetogenic CD8+ T cells. CD11c+ DCs from NOD.hCD205 mice are able to process and.

Vaginal CD11c+ DCs from IL-17A−/− mice are impaired in potentiating Th17 responses because of diminished IL-1β production. Vaginal CD11c+ DCs from IL-17A−/−

CD4+ memory T cells derived from either CD25hi or CD25lo effector cells respond robustly to secondary challenge. CD4+ memory T cells derived from either.

Immunization regimens that include a GLA-SE-formulated protein vaccine generate memory CD4 T cells. Immunization regimens that include a GLA-SE-formulated.

CD25 expression predicts effector and memory differentiation.

Dual blockade of PD-1 and CTLA-4 directly activates CD4+Foxp3− cells in the absence of CD8+ or CD4+Foxp3+ cells. Dual blockade of PD-1 and CTLA-4 directly.

B- and T-cell activity induced by immunization.

Hypoxic Ag-specific CD8+ T cells are less functional and less proliferative. Hypoxic Ag-specific CD8+ T cells are less functional and less proliferative.

Trametinib and combination promote moDC maturation and decrease moDC viability. Trametinib and combination promote moDC maturation and decrease moDC viability.

Mice with a B cell–specific deletion of Ets1 have increased memory phenotype B cells but no increase in switching to IgG1. Mice with a B cell–specific.

Anti-CD40 activates TAMs and recruits inflammatory monocytes.

Hypoxia upregulates CD137 expression in T lymphocytes undergoing activation. Hypoxia upregulates CD137 expression in T lymphocytes undergoing activation.

Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.

E2 induces IL-17–producing γδ+ T cells in the FGT

Bb monocolonization enhances Treg population in the cLP.

Surface expression of chemokine receptors on M

IL-17 produced by innate sources in the FGT is critical for potentiating Th17 responses primed by vaginal APCs. Vaginal cells from hormone cycle–matched.

Presentation transcript:

CD8α+, CD8α−, and MoDCs from NOD.hCD205 mice express hCD205. CD8α+, CD8α−, and MoDCs from NOD.hCD205 mice express hCD205. (A) Expression of hCD205 by splenocytes from C57BL/6 and NOD mice with and without hCD205 (three female mice per group; 15–19 wk old) was analyzed by flow cytometry. (B) hCD205 expression by splenic CD8α+, CD8α−, and MoDCs from C57BL6 (white) and NOD (black) hCD205-transgenic mice. Graph depicts mean MFI + SEM; p values are indicated (t test). Mono, monocytes. Jennifer Schloss et al. ImmunoHorizons 2019;3:236-253 Copyright © 2019 The Authors