Yohei Hayashi, Ph. D. , Mitinori Saitou, M. D. , Ph. D

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Germline development from human pluripotent stem cells toward disease modeling of infertility Yohei Hayashi, Ph.D., Mitinori Saitou, M.D., Ph.D., Shinya Yamanaka, M.D., Ph.D. Fertility and Sterility Volume 97, Issue 6, Pages 1250-1259 (June 2012) DOI: 10.1016/j.fertnstert.2012.04.037 Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Schematic representations of human germline development revealed by in vivo and in vitro approaches. hEGC = human embryonic germ cell; hESC = human embryonic stem cell; PGC = primordial germ cell. Fertility and Sterility 2012 97, 1250-1259DOI: (10.1016/j.fertnstert.2012.04.037) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Schematic representations of possible strategies of in vitro disease modeling using hESCs/iPSCs. ESC = embryonic stem cell; hESC = human embryonic stem cell; iPSC = induced pluripotent stem cell; PGC = primordial germ cell; POF = premature ovarian failure; POI = primary ovarian insufficiency. Fertility and Sterility 2012 97, 1250-1259DOI: (10.1016/j.fertnstert.2012.04.037) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions