Conserved and divergent elements of EPI and PrE transcription factor networks. Conserved and divergent elements of EPI and PrE transcription factor networks.

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Conserved and divergent elements of EPI and PrE transcription factor networks. Conserved and divergent elements of EPI and PrE transcription factor networks. (A) Intersection of transcription factors specific to EPI [FPKM>5 in EPI and not significantly (P>0.05) upregulated in PrE]. (B) Protein-protein interaction network of primate-specific EPI transcription factors. Node sizes are scaled to normalised expression in human and marmoset; edges are derived from the STRING database. (C) EPI-enriched transcription factors (circles) and chromatin remodelling factors (squares). Axes show the relative fraction of expression in the EPI between mouse and human (x), human and marmoset (y), and marmoset and mouse (z). (D) Selected markers representing normalised expression in ICM, EPI and PrE. (E) Sequentially activated canonical mouse PrE markers expressed in mouse (blue), marmoset (orange) and human (red). (F) Protein-protein interaction network of primate-specific PrE transcription factors [FPKM>5 in PrE and not significantly (P>0.05) upregulated in EPI]. As in B, node sizes are scaled to normalised expression in human and marmoset and edges are derived from the STRING database. Thorsten Boroviak et al. Development 2018;145:dev167833 © 2018. Published by The Company of Biologists Ltd