Volume 133, Issue 4, Pages (October 2007)

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Presentation transcript:

Volume 133, Issue 4, Pages 1113-1123 (October 2007) Altered Rectal Perception in Irritable Bowel Syndrome Is Associated With Symptom Severity Iris Posserud, Alma Syrous, Lina Lindström, Jan Tack, Hasse Abrahamsson, Magnus Simrén Gastroenterology Volume 133, Issue 4, Pages 1113-1123 (October 2007) DOI: 10.1053/j.gastro.2007.07.024 Copyright © 2007 AGA Institute Terms and Conditions

Figure 1 The individual symptoms included in the GSRS-IBS divided into 5 different domains. The symptoms are scored on a 7-grade Likert scale ranging from ”no discomfort” to ”very severe discomfort.”30 Gastroenterology 2007 133, 1113-1123DOI: (10.1053/j.gastro.2007.07.024) Copyright © 2007 AGA Institute Terms and Conditions

Figure 2 Box-and-whisker plots (extreme values and outliers not shown) demonstrating the data distribution in control subjects and patients with IBS of (A) the rectal discomfort threshold (mm Hg), (B) the rectal pain threshold (mm Hg), (C) VAS for unpleasantness (mm; mean of the first 4 distentions), and (D) the viscerosomatic referral area for nonpainful sensations (cm2). ****P < .0001. Gastroenterology 2007 133, 1113-1123DOI: (10.1053/j.gastro.2007.07.024) Copyright © 2007 AGA Institute Terms and Conditions

Figure 3 Sensory thresholds in female and male patients with IBS. *P < .05; **P < .01. Gastroenterology 2007 133, 1113-1123DOI: (10.1053/j.gastro.2007.07.024) Copyright © 2007 AGA Institute Terms and Conditions

Figure 4 The proportion having at least moderate symptom severity (mean scores on GSRS-IBS domains ≥4) in the groups with altered vs normal rectal perception, as well as the proportion of patients having clinically significant anxiety and depression according to HAD (score on HAD anxiety or HAD depression ≥11). Shown also is the proportion of patients in the respective groups having a GSRS mean total score ≥4, meaning at least moderate GI symptom severity overall (total GI symptoms [sx]). *P < .05; **P < .01; ****P < .0001. Gastroenterology 2007 133, 1113-1123DOI: (10.1053/j.gastro.2007.07.024) Copyright © 2007 AGA Institute Terms and Conditions