CD4+CLA+CD103+ T cells in skin and blood are clonally related.

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CD4+CLA+CD103+ T cells in skin and blood are clonally related. CD4+CLA+CD103+ T cells in skin and blood are clonally related. TCRβ sequencing was performed on sorted CLA+ memory CD4+ T cell subsets (as in Fig. 4) from blood and skin sorted on the basis of the expression of CD103 and CCR7 as indicated. (A) Left: Circle plot of unique productive TCRβ sequences from each of the indicated populations of CLA+ T cells from one representative donor (donor 1). Connections highlight sequences from skin CLA+CD103+ T cells found in each of the other populations. For visualization, sequences were downsampled (weighted for relative abundance) for populations containing >1000 unique sequences. Right: Graphical summary of the Morisita index as a measure of TCR repertoire similarity over all productive rearrangements between CLA+CD103+ T cells in the blood and each of the indicated populations across all four donors examined. (B) Circle plot (left) and graphical summary of the Morisita index (right) as in (A) using CLA+CD103+ T cells from blood as the reference population. Significance was determined by one-way ANOVA with Dunnett’s multiple comparisons test. Maria M. Klicznik et al. Sci. Immunol. 2019;4:eaav8995 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works