Esophageal eosinophilia caused by milk proteins: From suspicion to evidence based on 2 case reports Soledad Terrados Cepeda, MD, Dario Antolin-Amerigo,

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Presentation transcript:

Esophageal eosinophilia caused by milk proteins: From suspicion to evidence based on 2 case reports Soledad Terrados Cepeda, MD, Dario Antolin-Amerigo, MD, Jose Ramóm Foruny, MD, Ana Saiz Gonzalez, MD Journal of Allergy and Clinical Immunology Volume 129, Issue 5, Pages 1416-1419 (May 2012) DOI: 10.1016/j.jaci.2012.03.008 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A and C, Patient 1 before challenge. Blocks were stained with hematoxylin and eosin, and immunohistochemistry was performed with anti-tryptase (CMA890, Cell Marque). B and D, Patient 1's biopsy specimens 48 hours after double-blind, placebo-controlled oral challenge with milk. Staining was with hematoxylin and eosin, and immunohistochemistry was performed with anti-tryptase (CMA890, Cell Marque). Journal of Allergy and Clinical Immunology 2012 129, 1416-1419DOI: (10.1016/j.jaci.2012.03.008) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Patient 2: basal esophageal endoscopic appearance. A, Eosinophils in patient 2 before challenge. The block was stained with hematoxylin and eosin showing eosinophils. B, Eosinophils in patient 2 after challenge. The block was stained with hematoxylin and eosin showing eosinophils. C, Mast cells in patient 2 before challenge. Immunohistochemistry was performed with anti-tryptase (CMA890, Cell Marque). D, Mast cells in patient 2 after challenge. Immunohistochemistry was performed with anti-tryptase (CMA890, Cell Marque). Journal of Allergy and Clinical Immunology 2012 129, 1416-1419DOI: (10.1016/j.jaci.2012.03.008) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions