Different Growth Patterns of Non-Small Cell Lung Cancer Represent Distinct Biologic Subtypes Peyman Sardari Nia, MD, Cecile Colpaert, MD, PhD, Peter.

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Different Growth Patterns of Non-Small Cell Lung Cancer Represent Distinct Biologic Subtypes Peyman Sardari Nia, MD, Cecile Colpaert, MD, PhD, Peter Vermeulen, MD, PhD, Joost Weyler, MD, PhD, Francesco Pezzella, MD, PhD, Paul Van Schil, MD, PhD, Eric Van Marck, MD, PhD The Annals of Thoracic Surgery Volume 85, Issue 2, Pages 395-405 (February 2008) DOI: 10.1016/j.athoracsur.2007.08.054 Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Classification of non-small cell lung cancer into the growth patterns based on morphologic characteristics of the tumor tissue at the invading front. The Annals of Thoracic Surgery 2008 85, 395-405DOI: (10.1016/j.athoracsur.2007.08.054) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Growth patterns of non-small cell lung cancer on a routine hematoxylin and eosin–stained and on CD34-Ki-67 double immunostained tissue sections. Destructive growth pattern (angiogenic): parenchymal structures of the lung are not preserved, but replaced by carcinoma cells and tumor-associated stroma (A) with formation of new blood vessels (B [arrow]). Papillary growth pattern (intermediate): the lung parenchyma has been preserved with formation of fibrovascular stalks originating from the alveolar septa (C) with formation of new blood vessels (D [arrow]). Alveolar growth pattern (nonangiogenic): the tumor cell nests fill the alveolar spaces with preservation of alveolar septa (E) and with cooption of alveolar blood vessels (F [arrow]) without formation of a tumor-associated stroma. The Annals of Thoracic Surgery 2008 85, 395-405DOI: (10.1016/j.athoracsur.2007.08.054) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 (A) Growth pattern and stage IA. Overall survival according to growth pattern for patients in stage IA (destructive versus papillary growth pattern, p = 0.038, and destructive versus alveolar growth pattern, p = 0.788). (B) Growth pattern and stage IB. Overall survival according to growth pattern for patients in stage IB (destructive versus papillary growth pattern, p = 0.250, and destructive versus alveolar growth pattern, p = 0.008). The Annals of Thoracic Surgery 2008 85, 395-405DOI: (10.1016/j.athoracsur.2007.08.054) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions