The role of indoor allergens in chronic allergic disease Thomas A.E. Platts-Mills, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 119, Issue 2, Pages 297-302 (February 2007) DOI: 10.1016/j.jaci.2006.12.647 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 The relevance of evolutionary distance to immunogenicity and cross-reactivity. Evolutionary distance is given as the length of time to a common ancestor with human beings. Major inhalant allergens are shown with an asterisk. Cross-reactive allergens include (1) scabies with dust mites, (2) cockroaches with ladybugs, and (3) dogs and cats. The mammalian allergens that induce tolerance are shown in red. Journal of Allergy and Clinical Immunology 2007 119, 297-302DOI: (10.1016/j.jaci.2006.12.647) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Asian ladybugs in the United States. Asian ladybugs, Harmonia axyridis, were introduced to the United States repeatedly between 1918 and 1990. They have become established in many states (gray), have been reported as a cause of allergic symptoms in 18 states (red), and have been investigated in 5 states (ladybugs). Journal of Allergy and Clinical Immunology 2007 119, 297-302DOI: (10.1016/j.jaci.2006.12.647) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions