Requirement for IL-13 Independently of IL-4 in Experimental Asthma

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Requirement for IL-13 Independently of IL-4 in Experimental Asthma by Gabriele Grünig, Martha Warnock, Adil E. Wakil, Rajeev Venkayya, Frank Brombacher, Donna M. Rennick, Dean Sheppard, Markus Mohrs, Debra D. Donaldson, Richard M. Locksley, and David B. Corry Science Volume 282(5397):2261-2263 December 18, 1998 ©1998 by American Association for the Advancement of Science

Figure 1 PAS-stained histologic sections of murine lungs. PAS-stained histologic sections of murine lungs. Arrowheads point to goblet cells within the respiratory epithelium. (A) Wild-type mice were primed with OVA and challenged with PBS intranasally. (B) Wild-type mice were administered IL-13 intranasally. (C) IL-4–deficient and (D) IL-4Rα–deficient mice were primed with OVA and challenged with OVA intranasally. Wild-type mice were primed with OVA and challenged intranasally with (E) OVA and human Fc control protein or with (F) OVA and IL-13R-Fc. Note the marked reduction in goblet cells in (D) and (F). Gabriele Grünig et al. Science 1998;282:2261-2263 ©1998 by American Association for the Advancement of Science

Figure 2 Effect of neutralization of IL-13. Effect of neutralization of IL-13. Primed wild-type mice were administered intranasally human immunoglobulin (Ig control), Ig control and OVA, or IL-13R-Fc and OVA as indicated by (+). Data for (A) AHR, (B) goblet cell score, and numbers of (C) eosinophils and (D) neutrophils in the BAL fluid are plotted as means ±SEM. *P < 0.05 relative to PBS and Ig control–treated mice; †P < 0.05 relative to OVA and Ig control–treated mice. Data are representative of at least two comparable experiments with four to eight mice per group. Gabriele Grünig et al. Science 1998;282:2261-2263 ©1998 by American Association for the Advancement of Science

Figure 3 Effect of recombinant IL-4 and IL-13. Effect of recombinant IL-4 and IL-13. Wild-type (WT), RAG1-deficient (RAG1−/−), and IL-4Rα–deficient (IL-4Rα–/–) mice were administered IL-4, IL-13, or control protein intranasally. Data for (A) AHR, (B) goblet cell score, and numbers of (C) eosinophils and (D) neutrophils in the BAL fluid are plotted as means ±SEM. *P < 0.05 relative to mice receiving control protein. Data are representative of at least two comparable experiments with four to eight mice per group. Gabriele Grünig et al. Science 1998;282:2261-2263 ©1998 by American Association for the Advancement of Science