Malaria Presented by, Mr. Jilo P Thomas Nursing Tutor College of Nursing Kishtwar

Name means “bad air”- A life-threatening parasitic disease 40% of the world’s population is at risk 90% of the deaths due to Malaria occur in Sub-Sahara Africa, mostly among young children. Around 400-900 million people are affected At least 2.7 million deaths annually. It is one of the major public health concerns

Anopheles mosquitoes as vectors what use is the vector genome sequence? what is the ecology of Anopheles? investigate the specificity of the vector as related to individual Plasmodium spp. using sequence data what is the vector geographic distribution with regards to Plasmodium infection? what are eradication strategies, and implications on Plasmodium genome evolution?

Development of Malaria vaccines why are they so difficult to develop? what is relationship to Plasmodium lifecycle? what epitopes do the vaccines target & why? what are the model organisms for vaccine development, and why? most new vaccines are recombinant. Why? can human vaccines work in other hosts? How does this relate to the vaccine targets?

Life Cycle of Malarial Parasite

Malaria as a global problem (ethics) how does economic and cultural development impact the incidence and/or severity of malaria? who pays for malaria? money time effort why should we be concerned if it's not in the U.S.? vaccination programs New Chemotherapy what are difficulties in implementing vaccination programs? who determines who gets vaccinated? who gets vaccinated?

Conclusion Malaria is a global problem that lends itself to a multilayered investigation with bioinformatics as a major component. The wealth of materials and the ongoing sequencing process make it possible to continually expand the investigation to encompass increasingly sophisticated students.