K. P. Mason, E. R. Kelhoffer, R Prescilla, M Mehta, J. C. Root, V. J

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Feasibility of measuring memory response to increasing dexmedetomidine sedation in children K.P. Mason, E.R. Kelhoffer, R Prescilla, M Mehta, J.C. Root, V.J. Young, F Robinson, R.A. Veselis British Journal of Anaesthesia Volume 118, Issue 2, Pages 254-263 (February 2017) DOI: 10.1093/bja/aew421 Copyright © 2017 The Author(s) Terms and Conditions

Fig 1 Individual probabilities (faint plots) of verbal responses (sedation) and subsequent recognition memory with time (s) as the predictor variable during the induction of dexmedetomidine sedation. Group average plots are indicated in bold. Probability of recognition memory consistently decayed before onset of sedation, and the distribution of time intervals between 50% probabilities are shown in part (B). Positive values indicate that 50% recognition memory occurred sooner than 50% sedation. British Journal of Anaesthesia 2017 118, 254-263DOI: (10.1093/bja/aew421) Copyright © 2017 The Author(s) Terms and Conditions

Fig 2 Individual probabilities (faint plots) of verbal responses (sedation) and subsequent recognition memory with predicted serum dexmedetomidine concentration (ng ml−1) as the predictor variable during the induction of dexmedetomidine sedation. Group average plots are indicated in bold. Probability of recognition memory consistently decayed at lower predicted concentrations than onset of sedation, and the distribution of concentrations differences between 50% probabilities are shown in part (B). Positive values indicate that 50% recognition memory occurred at a lower concentration than 50% sedation. British Journal of Anaesthesia 2017 118, 254-263DOI: (10.1093/bja/aew421) Copyright © 2017 The Author(s) Terms and Conditions