Fig. 2 Exercise training potentiates synaptic transmissions via mTOR activation. Exercise training potentiates synaptic transmissions via mTOR activation.

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Fig. 2 Exercise training potentiates synaptic transmissions via mTOR activation. Exercise training potentiates synaptic transmissions via mTOR activation. (A) Illustration for whole-cell recordings of mEPSC of L5PRN in Thy1-YFP mice. (B) Schematic diagram for experimental protocols. Rapamycin administration was executed every 3 days during 21-day treadmill training. D0, day 0. (C) Bright-field (left) and epifluorescent (right) images of one YFP-labeled L5PRN for the whole-cell recording. (D to G) From left to right, representative traces of mEPSC extracted from nonrunner + saline (n = 8 neurons from four mice), runner + saline (n = 7 neurons from three mice), nonrunner + rapamycin (n = 8 neurons from four mice), and runner + rapamycin groups (n = 8 neurons from three mice). (H to K) Cumulative distributions of mEPSC amplitudes (H) and mEPSC frequencies (J) were plotted. Quantitative analysis (I and K) showed elevated mEPSC amplitudes in runner mice [one-way analysis of variance (ANOVA), F3,27 = 32.64, P < 0.0001; Tukey post hoc comparison, q27 = 4.966, P = 0.0081 (I)] that was subsequently abolished by rapamycin (q27 = 12.95, P < 0.0001). No significant change was found in mEPSC frequencies [q27 = 0.7616, P = 0.9488 for nonrunner + saline versus runner + saline and q27 = 3.112, P = 0.1487 for runner + saline versus runner + rapamycin (K)]. **P < 0.01, ***P < 0.001. Error bars, SEM. Kai Chen et al. Sci Adv 2019;5:eaaw1888 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).