Protective effect of inhibitors of neuronal toxicity of glutamate analog (HCA) in erastin-induced death in HT1080 cells. Protective effect of inhibitors.

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Protective effect of inhibitors of neuronal toxicity of glutamate analog (HCA) in erastin-induced death in HT1080 cells. Protective effect of inhibitors of neuronal toxicity of glutamate analog (HCA) in erastin-induced death in HT1080 cells. A, Dose–responses of chemical inhibitors effective in HCA-induced neuronal toxicity. Values represent mean ± SD, except for Adaptaquin, Apicidin, and Scriptaid, where medians are given. *p < 0.05 versus erastin. B, Gene expression levels of Mithramycin target genes c-Myc and p21 were assessed in HT1080 cells exposed to 50 or 300 nm Mithramycin. Values represent medians. *p = 0.009 versus vehicle. C, Dose–responses of Scriptaid and Nullscript (negative control) in erastin-induced cell death in primary cortical neurons (PCNs). Values represent mean ± SD, *p < 0.05 versus erastin, #p < 0.05 versus Nullscript (negative control). D, Protein levels of acetylated and total histone H4 were assessed in HT1080 cells exposed to Scriptaid or its inactive analog Nullscript. E, Gene expression of HDACs from class I in PCNs versus HT1080 cells. Values represent medians. *p < 0.0125 versus PCNs. For exact p values refer to Figures 13-1, 13-2, 13-3, and 13-4. Marietta Zille et al. eNeuro 2019;6:ENEURO.0263-18.2019 ©2019 by Society for Neuroscience