Prognostic Significance of Simultaneous Measurement of Three Tumor Markers in Patients With Hepatocellular Carcinoma Hidenori Toyoda, Takashi Kumada,

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Prognostic Significance of Simultaneous Measurement of Three Tumor Markers in Patients With Hepatocellular Carcinoma Hidenori Toyoda, Takashi Kumada, Seiki Kiriyama, Yasuhiro Sone, Makoto Tanikawa, Yasuhiro Hisanaga, Akihiro Yamaguchi, Masatoshi Isogai, Yuji Kaneoka, Junji Washizu Clinical Gastroenterology and Hepatology Volume 4, Issue 1, Pages 111-117 (January 2006) DOI: 10.1016/S1542-3565(05)00855-4 Copyright © 2006 American Gastroenterological Association Terms and Conditions

Figure 1 Distribution of patients with various patterns of positivity for the 3 tumor markers of HCC. Clinical Gastroenterology and Hepatology 2006 4, 111-117DOI: (10.1016/S1542-3565(05)00855-4) Copyright © 2006 American Gastroenterological Association Terms and Conditions

Figure 2 Survival of patients not positive for a tumor marker and patients positive for only 1 tumor marker (AFP, AFP-L3, and DCP) (patients not positive for a tumor marker vs patients positive for only DCP, P = .0014). Clinical Gastroenterology and Hepatology 2006 4, 111-117DOI: (10.1016/S1542-3565(05)00855-4) Copyright © 2006 American Gastroenterological Association Terms and Conditions

Figure 3 Patient survival according to the number of tumor markers present (patients not positive for a tumor marker vs patients positive for only 1 tumor marker, P = .0181; patients positive for only 1 tumor marker vs patients positive for 2 tumor markers, P = .0141; patients positive for 2 tumor markers vs patients positive for 3 tumor markers, P < .0001). Clinical Gastroenterology and Hepatology 2006 4, 111-117DOI: (10.1016/S1542-3565(05)00855-4) Copyright © 2006 American Gastroenterological Association Terms and Conditions

Figure 4 Changes in the number of tumor markers present before and after treatment of HCC (hepatectomy and TACE, before treatment vs after treatment, P < .0001; LAT, before treatment vs after treatment, P = .0005). Clinical Gastroenterology and Hepatology 2006 4, 111-117DOI: (10.1016/S1542-3565(05)00855-4) Copyright © 2006 American Gastroenterological Association Terms and Conditions