Leptin-induced LTP at TA-CA1 synapses involves a postsynaptic expression mechanism. Leptin-induced LTP at TA-CA1 synapses involves a postsynaptic expression.

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Leptin-induced LTP at TA-CA1 synapses involves a postsynaptic expression mechanism. Leptin-induced LTP at TA-CA1 synapses involves a postsynaptic expression mechanism. A, Plot of pooled and normalized data illustrating the effects of 100 nm (15 min) leptin on excitatory synaptic transmission evoked at TA-CA1 synapses. Calibration: 0.1 mV, 20 ms. B, Corresponding plot of the pooled PPR against time for the experiments shown in A. The effects of leptin on synaptic transmission were not accompanied by any significant change in PPR. In contrast, the synaptic depression induced by DA is accompanied by a significant alteration in PPR. Above the plots are representative pairs of fEPSPs evoked with a 50 ms interstimulus interval at the times indicated. Xiao Luo et al. eneuro 2015;2:ENEURO.0007-15.2015 ©2015 by Society for Neuroscience