Dancing with the Stars: Phenolic Glycolipids Partners with Macrophages Micah D. Dunlap, Shabaana A. Khader  Cell Host & Microbe  Volume 22, Issue 3, Pages 249-251 (September 2017) DOI: 10.1016/j.chom.2017.08.016 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Mycobacterial PGLs Partner with Macrophages to Promote Nerve Demyelination Tissue resident macrophages (Mɸs) phagocytose PGL-1 expressing Mycobacterium leprae (Mlep). PGL-mediated activation of the intracellular PAMP sensor STING induces CCL2 production, which recruits permissive CCR2-expressing monocytes to sustain infection. Infected and uninfected macrophages also leave the tissue and patrol nerve axons, where Mlep PGL-1 induces expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in infected macrophages. NO production by Mlep infected macrophages leads to mitochondrial damage and demyelination of neurons. Cell Host & Microbe 2017 22, 249-251DOI: (10.1016/j.chom.2017.08.016) Copyright © 2017 Elsevier Inc. Terms and Conditions