Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line  Miguel Angel García-Pérez, Ph.D., Begoña Pineda, B.Sc., Carlos Hermenegildo, M.D., Ph.D., Juan J. Tarín, Ph.D., Antonio Cano, M.D., Ph.D.  Fertility and Sterility  Volume 91, Issue 4, Pages 1347-1350 (April 2009) DOI: 10.1016/j.fertnstert.2008.03.042 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Effects of Cimicifuga racemosa on bone as reflected by changes in bone markers in women (panel A), or cell activity and gene expression (panels B and C, respectively) in the MC3T3-E1 osteoblastic cell line. The data represent the mean ± standard error of the mean and are expressed as the ratio to their corresponding baseline values. White boxes: untreated control. Black boxes: treatment with Cimicifuga racemosa. NTx: N-telopeptide of type I collagen. Ca/Cr: calcium–creatinine ratio. ALP: alkaline phosphatase. β-GP: β-glycerophosphate. Runx-2: Runt-related transcription factor-2. ∗P<.05 when comparing both groups. Fertility and Sterility 2009 91, 1347-1350DOI: (10.1016/j.fertnstert.2008.03.042) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions