Randomized Controlled Trial of Calcium in Healthy Older Women

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Presentation transcript:

Randomized Controlled Trial of Calcium in Healthy Older Women Ian R. Reid, MD, Barbara Mason, BSc, Anne Horne, MBChB, Ruth Ames, NZCS, Helen E. Reid, BSc, Usha Bava, MHSc, Mark J. Bolland, MBChB, Gregory D. Gamble, MSc The American Journal of Medicine Volume 119, Issue 9, Pages 777-785 (September 2006) DOI: 10.1016/j.amjmed.2006.02.038 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Subject disposition. The American Journal of Medicine 2006 119, 777-785DOI: (10.1016/j.amjmed.2006.02.038) Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 2 Effects of calcium supplementation on changes in bone mineral density over 5 years. Data are mean±standard error of mean (SEM), and based on the intention-to-treat cohort. Treatment effects were significant at each site (P < .0001). The American Journal of Medicine 2006 119, 777-785DOI: (10.1016/j.amjmed.2006.02.038) Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 3 Effects of calcium supplementation on changes in bone mineral density over 5 years. Data are mean±SEM, and based on the per-protocol cohort. Treatment effects were significant at each site (P < .0001). The American Journal of Medicine 2006 119, 777-785DOI: (10.1016/j.amjmed.2006.02.038) Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 4 Cumulative fracture incidence over time (Kaplan-Meier plots) in the intention-to-treat population. Significance of effects is shown in Table 2. The American Journal of Medicine 2006 119, 777-785DOI: (10.1016/j.amjmed.2006.02.038) Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 5 Cumulative fracture incidence over time (Kaplan-Meier plots) in the per-protocol population with medication compliance greater than 60%. Significance of effects is shown in Table 2. The American Journal of Medicine 2006 119, 777-785DOI: (10.1016/j.amjmed.2006.02.038) Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 6 Effects of calcium supplementation on changes in serum alkaline phosphatase (ALP) activity from baseline to 5 years (upper). Values were comparable in the groups at baseline (85±20 in each group) but decreased more in the calcium group (P <.0001). Data are mean±SEM. Procollagen type-I N-terminal propeptide (PINP) levels at 5 years in 40 subjects from each group (lower). Values are significantly lower in the calcium group. The American Journal of Medicine 2006 119, 777-785DOI: (10.1016/j.amjmed.2006.02.038) Copyright © 2006 Elsevier Inc. Terms and Conditions