Circular plots of 20 regulators reveal redundancies and serial inhibition (10, 12). Circular plots of 20 regulators reveal redundancies and serial inhibition.

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Circular plots of 20 regulators reveal redundancies and serial inhibition (10, 12). Circular plots of 20 regulators reveal redundancies and serial inhibition (10, 12). They represent peak phases of mRNA expression in multiple tissues (3). Note that repressor phases were inverted by 12 h to allow direct comparison with activators. (A) Histogram of the phase distribution over all tissues. (B) List of genes represented in circular plots and their corresponding target motifs. Repressors are marked in bold. (C) Phases of core clock genes in selected tissues. Colored lines correspond to the circular mean of the respective groups. Amplitudes are linearly scaled. The differences between SCN and other tissues are particularly notable (e.g., the earlier Cry1 peak). Antagonistic regulations of Rev-erb and Ror in the SCN can be modeled by reduced inhibition strength of Rev-erb-α. J Patrick Pett et al. LSA 2018;1:e201800078 © 2018 Pett et al.