Pulmonary hypertension is associated with worse early and late outcomes after aortic valve replacement: Implications for transcatheter aortic valve replacement

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Presentation transcript:

Pulmonary hypertension is associated with worse early and late outcomes after aortic valve replacement: Implications for transcatheter aortic valve replacement Eric E. Roselli, MD, Anas Abdel Azim, MD, MSc, Penny L. Houghtaling, MS, Wael A. Jaber, MD, Eugene H. Blackstone, MD The Journal of Thoracic and Cardiovascular Surgery Volume 144, Issue 5, Pages 1067-1074.e2 (November 2012) DOI: 10.1016/j.jtcvs.2012.08.029 Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Cumulative distribution of pulmonary hypertension as assessed by right ventricular systolic pressure (RVSP). The Journal of Thoracic and Cardiovascular Surgery 2012 144, 1067-1074.e2DOI: (10.1016/j.jtcvs.2012.08.029) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Trends in right ventricular systolic pressure (RVSP) after aortic valve replacement. Symbols represent data grouped within time frames, without regard for repeated assessment, simply to provide crude verification of model fit. Larger symbols depict preoperative mean values. preop, Preoperative. A, Entire cohort. B, Stratified by preoperative RVSP. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 1067-1074.e2DOI: (10.1016/j.jtcvs.2012.08.029) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Survival after aortic valve replacement stratified by preoperative right ventricular systolic pressure (RVSP). Each symbol represents a death, vertical bars are 68% confidence limits representing ±1 standard error, and numbers below horizontal axis are patients remaining at risk. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 1067-1074.e2DOI: (10.1016/j.jtcvs.2012.08.029) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Predicted 5-year survival after aortic valve replacement as assessed by right ventricular systolic pressure (RVSP). Solid line is parametric estimate enclosed within dashed 68% confidence limits representing ±1 standard error. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 1067-1074.e2DOI: (10.1016/j.jtcvs.2012.08.029) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Number of patients with echocardiograms available at and beyond various time points, and number of echocardiograms available for analysis. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 1067-1074.e2DOI: (10.1016/j.jtcvs.2012.08.029) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions