Volume 393, Issue 10190, Pages (June 2019)

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Volume 393, Issue 10190, Pages 2511-2520 (June 2019) Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial Prof Jonathan D C Ross, MD, Clare Brittain, BMedSc, Michelle Cole, DBMS, Claire Dewsnap, MD, Jan Harding, PhD, Trish Hepburn, BSc, Louise Jackson, PhD, Matthew Keogh, Tessa Lawrence, PhD, Prof Alan A Montgomery, PhD, Prof Tracy E Roberts, PhD, Kirsty Sprange, MSc, Wei Tan, MSc, Sukhwinder Thandi, PhD, John White, FRCP, Janet Wilson, FRCP, Prof Lelia Duley, MD The Lancet Volume 393, Issue 10190, Pages 2511-2520 (June 2019) DOI: 10.1016/S0140-6736(18)32817-4 Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Terms and Conditions

Figure 1 Trial profile The Lancet 2019 393, 2511-2520DOI: (10.1016/S0140-6736(18)32817-4) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Terms and Conditions

Figure 2 Sensitivity analyses of Neisseria gonorrhoeae clearance at all sites The red line indicates the −5% non-inferiority margin. BD=Becton Dickinson. AC=Aptima Combo. NAAT=nucleic acid amplification test. *Age, gender, ethnicity, country of birth, and past history of gonorrhoea were included in the multiple imputation with chained equations. The Lancet 2019 393, 2511-2520DOI: (10.1016/S0140-6736(18)32817-4) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Terms and Conditions

Figure 3 Pre-treatment MICs of gentamicin, ceftriaxone, and azithromycin (A) Distribution of gentamicin MICs by treatment response in 132 participants who received gentamicin. (B) Distribution of ceftriaxone MICs by treatment response in 145 participants who received ceftriaxone. Azithromycin MICs for the four participants who did not clear were 0·125 mg/L (cervix), 0·125 mg/L (rectum), 0·125 mg/L (pharynx), and 0·25 mg/L (urethra). (C) Distribution of azithromycin MICs by treatment response in 276 participants who received azithromycin. MIC=minimum inhibitory concentration. The Lancet 2019 393, 2511-2520DOI: (10.1016/S0140-6736(18)32817-4) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Terms and Conditions