Glomerulus from a patient with primary membranous nephropathy showing the pathognomonic “spikes” of basement membrane projecting from the outer surface of the glomerular basement membrane (arrows) when stained with silver-methenamine (original magnification... Glomerulus from a patient with primary membranous nephropathy showing the pathognomonic “spikes” of basement membrane projecting from the outer surface of the glomerular basement membrane (arrows) when stained with silver-methenamine (original magnification, ×40). (Provided by Dr. Charles Alpers, Department of Pathology, University of Washington, Seattle, WA.) William G. Couser CJASN 2017;12:983-997 ©2017 by American Society of Nephrology