Peter A. McCullough et al. JACC 2016;68:

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Peter A. McCullough et al. JACC 2016;68:1465-1473 Anatomy of a Single Nephron and Location of Novel and Conventional Biomarkers of Renal Filtration and Tubular Epithelial Cell Damage Markers of filtration indicate transient reductions in glomerular function, whereas cell damage markers indicate cellular injury, and the 2 together have a poorer prognosis than either alone. Not all of these markers have been validated for CI-AKI. Cell cycle arrest markers are TIMP2*IGFBP-7 (tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein-7). CI-AKI = contrast-induced acute kidney injury; GST = glutathione S-transferase; IL = interleukin; KIM = kidney injury molecule; L-FABP = L-type fatty-acid binding protein; NAG = N-acetyl-beta-D-glucosaminidase; NGAL = neutrophil gelatinase-associated lipocalin. Peter A. McCullough et al. JACC 2016;68:1465-1473 2016 American College of Cardiology Foundation