Vasopressin antagonists in polycystic kidney disease

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Vasopressin antagonists in polycystic kidney disease Vicente E. Torres Kidney International Volume 68, Issue 5, Pages 2405-2418 (November 2005) DOI: 10.1111/j.1523-1755.2005.00703.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Renal imaging studies illustrating the evolution of polycystic kidney disease in patient 1. Axial computed tomography images from 1991 and 1999 (A and B) and coronal T2-weighted images from 1999 and 2004 (C and D) showing the increase in total kidney and cyst volumes and the reduction in parenchymal volume between 1991 and 2004. Kidney International 2005 68, 2405-2418DOI: (10.1111/j.1523-1755.2005.00703.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Changes in total kidney volume, iothalamate clearance, serum creatinine concentration, and urine osmolality values over time in patients 1 and 2. The first total kidney volume in patient 1 (age 17 years) was derived from the renal ultrasound using the ellipsoid formula. The remaining total kidney volumes were measured using computed tomography or magnetic resonance images. Kidney International 2005 68, 2405-2418DOI: (10.1111/j.1523-1755.2005.00703.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Renal imaging studies illustrating the evolution of polycystic kidney disease in patient 1. Excretory urograms in 1972 show an enlarged right kidney with a delayed and prolonged nephrogram (A and B). Axial computed tomography images (C and D) showing the increase in total kidney and cyst volume between 1999 and 2003; note also the development of aortic wall calcification. Kidney International 2005 68, 2405-2418DOI: (10.1111/j.1523-1755.2005.00703.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 4 Effects of OPC-31260 on the development of polycystic kidney disease. Administration of OPC-31260 to male pcy mice (0.1%, 4-30 weeks), PCK rats (0.1%, 3-10 weeks), and Pkd2WS25/- mice (0.05%, 3-16 weeks) at the specified concentrations and ages markedly inhibited renal enlargement (upper panel). Representative kidney sections from control (A and B) and treated (D and E) pcy mice and PCK rats. Kidney sections from the most severely affected control (C) and treated (F) Pkd2WS25/- mice. Modified from[9], [10]. Kidney International 2005 68, 2405-2418DOI: (10.1111/j.1523-1755.2005.00703.x) Copyright © 2005 International Society of Nephrology Terms and Conditions