Examples of tumors represented in Tp53Δ11/Δ11 and Tp53Δ11/+ rats.

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Examples of tumors represented in Tp53Δ11/Δ11 and Tp53Δ11/+ rats. Examples of tumors represented in Tp53Δ11/Δ11 and Tp53Δ11/+ rats. The most common tumors of our TP53-deficient rats involved the CNS, blood vessels, bone and mammary gland: (A) meningeal sarcoma (CNS), (B) astrocytoma (CNS), (C) neuroblastoma (CNS), (D) epithelioid hemangiosarcoma (blood vessels), (E) osteosarcoma (bone) and (F) mammary carcinoma. Aaron McCoy et al. Dis. Model. Mech. 2013;6:269-278 © 2012. Published by The Company of Biologists Ltd