Does “autoreactivity” play a role in atopic dermatitis?

Slides:

Advertisements

Similar presentations

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

Advertisements

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Does BCG vaccination protect against childhood asthma

Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2.

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

“Inflammatory skin march”: IL-1–mediated skin inflammation, atopic dermatitis, and psoriasis to cardiovascular events Keiichi Yamanaka, MD, PhD, Hitoshi.

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Doina M. Racila, MD, Joel N. Kline, MD, MSc

Natalija Novak, MD Journal of Allergy and Clinical Immunology

Fatty acids, inflammation, and asthma

Endotype-driven care pathways in patients with chronic rhinosinusitis

Advances in food allergy in 2015

IL-17–producing T cells in lung immunity and inflammation

Reduced IFN-γ receptor expression and attenuated IFN-γ response by dendritic cells in patients with atopic dermatitis Eva Gros, MSc, Susanne Petzold,

Atopic dermatitis: Age and race do matter!

The role of air pollutants in atopic dermatitis

Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis Julia K. Gittler, BA, James G. Krueger,

Maritta S. Jaakkola, MD, PhD, Reginald Quansah, PhD, Timo T

Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2.

Therapeutic pipeline for atopic dermatitis: End of the drought?

Is 9 more than 2 also in allergic airway inflammation?

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Interplay between the skin barrier and immune cells in patients with atopic dermatitis unraveled by means of mathematical modeling David Bending, PhD,

Fatty acids, inflammation, and asthma

Reversal of atopic dermatitis with narrow-band UVB phototherapy and biomarkers for therapeutic response Suzanne Tintle, BS, Avner Shemer, MD, Mayte Suárez-Fariñas,

An Infant with Atopic Dermatitis and Itching After Ingestion of Milk

Rising prevalence of asthma is sex-specific in a US farming population

BCG vaccination and allergy: A systematic review and meta-analysis

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria Tse Wen Chang, PhD, Christina Chen, BS, Chien-Jen.

Advances in atopic dermatitis and urticarial in 2016

Expression of FcɛRI on dendritic cell subsets in peripheral blood of patients with atopic dermatitis and allergic asthma Inge M.J. Beeren, MSc, Marjolein.

Etiology of asthma exacerbations

Are the concepts of induction of remission and treatment of subclinical inflammation in atopic dermatitis clinically useful? Ting Seng Tang, MBBS, Thomas.

Does BCG vaccination protect against childhood asthma

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Biologics and biomarkers for asthma, urticaria, and nasal polyposis

Reply Journal of Allergy and Clinical Immunology

Thymic stromal lymphopoietin–activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis Wen Hao Wu, PhD,

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

Roles of arginase variants, atopy, and ozone in childhood asthma

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

What are the best outcome measurements for atopic eczema

Is eczema really on the increase worldwide?

Atopic dermatitis: A practice parameter update 2012

Cellular and molecular immunologic mechanisms in patients with atopic dermatitis Thomas Werfel, MD, Jean-Pierre Allam, MD, Tilo Biedermann, MD, Kilian.

Biosimilars and drug development in allergic and immunologic diseases

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

The role of the T cell in asthma

Personalized asthma therapy in blacks—the role of genetic ancestry

Autophagy: Nobel Prize 2016 and allergy and asthma research

Aaron M. Drucker, MD, Paula J. Harvey, PhD

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

New pathways for itching in patients with atopic dermatitis?

The role of atopic sensitization in flexural eczema: Findings from the International Study of Asthma and Allergies in Childhood Phase Two Carsten Flohr,

Susan A. Rudders, MD, Sarah A. Arias, PhD, Carlos A

Reply Journal of Allergy and Clinical Immunology

Expression of chemokines and chemokine receptors in lesional and nonlesional upper skin of patients with atopic dermatitis Eva Gros, MSc, Caroline Bussmann,

Systemic and localized seminal plasma hypersensitivity patients exhibit divergent immunologic characteristics Debajyoti Ghosh, PhD, Jonathan A. Bernstein,

Epicutaneous application of house dust mite induces thymic stromal lymphopoietin in nonlesional skin of patients with atopic dermatitis Janneke Landheer,

Human basophils may not undergo modulation by DC-SIGN and mannose receptor– targeting immunotherapies due to absence of receptors Mrinmoy Das, MSc, Caroline.

Immune pathomechanism of drug hypersensitivity reactions

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy.

Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization.

Molecular and cellular mechanisms of food allergy and food tolerance

Contrasting pathogenesis of atopic dermatitis and psoriasis—Part II: Immune cell subsets and therapeutic concepts Emma Guttman-Yassky, MD, PhD, Kristine.

Epidermal thymic stromal lymphopoietin predicts the development of atopic dermatitis during infancy Jihyun Kim, MD, PhD, Byung Eui Kim, MD, PhD, Jeongok.

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Presentation transcript:

Does “autoreactivity” play a role in atopic dermatitis? Ting Seng Tang, BSc, MBBS, Thomas Bieber, MD, PhD, Hywel C. Williams, MSc, PhD Journal of Allergy and Clinical Immunology Volume 129, Issue 5, Pages 1209-1215.e2 (May 2012) DOI: 10.1016/j.jaci.2012.02.002 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Study flow diagram. Journal of Allergy and Clinical Immunology 2012 129, 1209-1215.e2DOI: (10.1016/j.jaci.2012.02.002) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Forest plot showing pooled analysis of the prevalence of IgE autoantibodies (Events) in subjects with eczema and control subjects. The weighted risk ratio was calculated by using the Mantel-Haenszel (M-H) statistical method and a random-effects model. Journal of Allergy and Clinical Immunology 2012 129, 1209-1215.e2DOI: (10.1016/j.jaci.2012.02.002) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Mechanisms of IgE sensitization to epidermal self-proteins in patients with AD. Inflammation induces pruritus through IL-31 production. Scratching results in cellular damage and release of membranous and intracellular compounds from keratinocytes (KC) and possibly other skin cells. The local dendritic cells (DC) subjected to thymic stromal lymphopoietin (TSLP) will induce a TH2 response and the generation of specific IgE directed against these self-proteins. IgE will bind to FcεRI on dendritic cells in the skin and thereby amplify the immune response and inflammatory reaction in the skin. Journal of Allergy and Clinical Immunology 2012 129, 1209-1215.e2DOI: (10.1016/j.jaci.2012.02.002) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Search strategy. Journal of Allergy and Clinical Immunology 2012 129, 1209-1215.e2DOI: (10.1016/j.jaci.2012.02.002) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions