OvulonaTM monitors the end-organ effect of all reproductive effectors by measuring bioelectronic admittance of the outer-cervix tissue OvulonaTM basic concept model (NOT showing real features): OvulonaTM monitors admittance of the exocervix, the outside of the end organ which integrates the effects of all key reproductive effectors. We call this FIVTM, or Folliculogenesis In VivoTM Key to FIV™: Cervix uteri receives endocrinological and neurological signals controlling reproduction Unlike other methods, FIVTM anticipates AND detects ovulation, and reflects processes that affect or are related to menstrual periodicity FERTILE DAY 1 Posterior Fornix The woman inserts the Ovulona™ device much like a tampon with its tip extending to the Posterior Fornix. Planned modification will be a telemetric vaginal insert obviating daily insertion.

Hormone levels in blood circulation during menstrual cycle Detecting the fertile window requires integration of all inputs into the system, received from the ovaries and from the brain Hormone levels in blood circulation during menstrual cycle Female Reproductive System Ovary Fallopian Tube Uterus Cervix Vagina fertile window Estrogen Follicle-Stimulating Hormone Luteinizing Hormone Progesterone The fertile window results from a complex interplay of multiple variables including signals from the brain, on which the ovary is “obligatorily dependent1,” sensitive to stress2 and affecting the timing and intensity of the mid-cycle LH surge3 Reproductive organs have a dense innervation and are under a local regulation of hormones, prostaglandins and other effectors The cervix is central to experiencing the results of the interplay of all these variables Monitoring the cervix yields information that circulating body-fluid hormones can’t provide All commercial products track only a single circulating hormone (or two in one case), and do so indirectly 1 "The hypothalamic pulse generator: The reproductive core,” J. Hotchkiss and E. Knobil, Chapter 7 in Reproductive Endocrinology, Surgery, and Technology, (editors: Adashi, Rock, and Rosenwaks) Lippincott - Raven, (1)124 – 162, 1996 2 “Brain opioid peptides and menstrual cyclicity,” P.R. Gindoff and M. Ferin, Seminars in Reproductive Endocrinology 5(125), 1987 3 "The gonads: Development & function of the reproductive system,” W. F. Ganong, Review of Medical Physiology, 17th edition, Chapter 23, Appleton & Lange, 1995

From patients’ Ovulona™ units to a physician’s Ovulograph™ Friendly Technology Ovulographic™ Folliculogenesis In Vivo™ (FIV™) screening concurrently cervical health Data From Home To Healthcare Providers Test in Posterior Fornix From patients’ Ovulona™ units to a physician’s Ovulograph™ – when needed Next generation telemetric embodiment for users’ convenience Folliculogenesis data correlated with auxiliary data (e.g. BBT) Importance of the topic: The quality of ovulation is strained in normal women - by Richard S. Legro, Human Reproduction, Vol.28, No.6 pp. 1446–1447, 2013 ‘Improve the methods and criteria used to assess ovulatory dysfunction’ - Click above on Ovulograph to view the shown graphical introduction to our solution