Deposition of fenoterol from pressurized metered dose inhalers containing hydrofluoroalkanes Stephen Newman, PhDa, Gary Pitcairn, PhDa, Karen Steed,

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Presentation transcript:

Deposition of fenoterol from pressurized metered dose inhalers containing hydrofluoroalkanes Stephen Newman, PhDa, Gary Pitcairn, PhDa, Karen Steed, MPhila, Aleck Harrison, BScb, Jürgen Nagel, PhDc Journal of Allergy and Clinical Immunology Volume 104, Issue 6, Pages s253-s257 (December 1999) DOI: 10.1016/S0091-6749(99)70042-4 Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 1 Radiolabeling validation data for (A ) chlorofluorocarbon product, (B ) hydrofluoroalkane-134a product, and (C ) hydrofluoroalkane-227 product. Distributions of drug before labelling (unlabelled drug), drug after labeling (labeled drug), and radiolabel are shown for each formulation in a multistage liquid impinger operated at 60 L/min. The impinger comprised a 90-degree inlet “throat”, 4 impaction stages (S1 to S4), and a wash bottle acting as a final filter. Journal of Allergy and Clinical Immunology 1999 104, s253-s257DOI: (10.1016/S0091-6749(99)70042-4) Copyright © 1999 Mosby, Inc. Terms and Conditions