Volume 79, Issue 5, Pages (March 2011)

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Volume 79, Issue 5, Pages 563-572 (March 2011) A genome-wide association study for diabetic nephropathy genes in African Americans Caitrin W. McDonough, Nicholette D. Palmer, Pamela J. Hicks, Bong H. Roh, S Sandy An, Jessica N. Cooke, Jessica M. Hester, Maria R. Wing, Meredith A. Bostrom, Megan E. Rudock, Joshua P. Lewis, Matthew E. Talbert, Rebecca A. Blevins, Lingyi Lu, Maggie C Y Ng, Michele M. Sale, Jasmin Divers, Carl D. Langefeld, Barry I. Freedman, Donald W. Bowden Kidney International Volume 79, Issue 5, Pages 563-572 (March 2011) DOI: 10.1038/ki.2010.467 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 1 Genome-wide association study results. The top hit was rs5750250 located on chromosome 22 in the MYH9 gene (P=3.00 × 10-7). Results are adjusted for admixture using PC1 as a covariate in the analysis. P-values are shown under the additive model. Chr, chromosome; MYH9, nonmuscle myosin heavy chain 9; PC1, first principal component. Kidney International 2011 79, 563-572DOI: (10.1038/ki.2010.467) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 2 All-cause ESRD candidate regions. (a) LIMK2-SFI1 gene region. (b) MYH9 gene region. -log10PADD values from the GWAS are plotted versus position (genome build 36). The large red diamond indicates PADD values from the GWAS of the marker(s) displayed. The large blue diamond and corresponding P-value indicates PADD values from the combined analysis of the marker(s) displayed. LD based on control samples is color coded: red (r2 to top SNP 0.8–1.0), orange (0.5–0.8), yellow (0.2–0.5), and white (<0.2). Gene annotations were obtained from UCSC Genome Browser (RefSeq Genes, b36). Arrows represent direction of transcription. ESRD, end-stage renal disease; GWAS, genome-wide association study; LD, linkage disequilibrium; MYH9, nonmuscle myosin heavy chain 9. Kidney International 2011 79, 563-572DOI: (10.1038/ki.2010.467) Copyright © 2011 International Society of Nephrology Terms and Conditions