Wilms Tumor 1 Expression and Pre-emptive Immunotherapy in Patients with Acute Myeloid Leukemia Undergoing an Allogeneic Hemopoietic Stem Cell Transplantation

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Presentation transcript:

Wilms Tumor 1 Expression and Pre-emptive Immunotherapy in Patients with Acute Myeloid Leukemia Undergoing an Allogeneic Hemopoietic Stem Cell Transplantation Carmen Di Grazia, Sarah Pozzi, Simona Geroldi, Raffaella Grasso, Maurizio Miglino, Nicoletta Colombo, Elisabetta Tedone, Silvia Luchetti, Teresa Lamparelli, Francesca Gualandi, Adalberto Ibatici, Stefania Bregante, Maria Teresa Van Lint, Anna Maria Raiola, Alida Dominietto, Riccardo Varaldo, Federica Galaverna, Anna Ghiso, Simona Sica, Andrea Bacigalupo Biology of Blood and Marrow Transplantation Volume 22, Issue 7, Pages 1242-1246 (July 2016) DOI: 10.1016/j.bbmt.2016.03.005 Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 WT1 copies/104 Abl in a 58-year-old patients with relapsed/refractory AML. CyA disc indicates cyclosporin A discontinuation; DLI, donor lymphocyte infusions. Biology of Blood and Marrow Transplantation 2016 22, 1242-1246DOI: (10.1016/j.bbmt.2016.03.005) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Cumulative incidence of relapse in MRD-positive patients treated with immunotherapy (IT) at a cut-off level of 180 copies/104 Abl (WT1-180) (n = 17) or 100 copies/104 Abl (WT1-100) (n = 23). Biology of Blood and Marrow Transplantation 2016 22, 1242-1246DOI: (10.1016/j.bbmt.2016.03.005) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Disease-free survival of MRD-positive patients treated with IT at a cut-off level of WT1 of 180 copies/104 Abl (WT1-180) (n = 17) or 100 copies/104 Abl (WT1-100) (n = 23). Biology of Blood and Marrow Transplantation 2016 22, 1242-1246DOI: (10.1016/j.bbmt.2016.03.005) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Overall cumulative incidence of TRM and of relapse in 122 patients, monitored for WT1 expression and eligible for IT at a cut-off of 180 copies (WT1-180) and in 85 patients monitored and eligible for IT at a cut-off level of 100 copies (WT1-100). Biology of Blood and Marrow Transplantation 2016 22, 1242-1246DOI: (10.1016/j.bbmt.2016.03.005) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 Overall disease-free survival of the 2 groups of AML patients, as described in Figure 4 (WT1-180 and WT1-100). Biology of Blood and Marrow Transplantation 2016 22, 1242-1246DOI: (10.1016/j.bbmt.2016.03.005) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions