Focal Cholesterol Granuloma in the Anterior Mediastinum: [18F]-Fluoro-2-Deoxy-D- Glucose-Positron Emission Tomography and Magnetic Resonance Imaging Findings

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Focal Cholesterol Granuloma in the Anterior Mediastinum: [18F]-Fluoro-2-Deoxy-D- Glucose-Positron Emission Tomography and Magnetic Resonance Imaging Findings Kiminori Fujimoto, MD, PhD, Shinzo Takamori, MD, Hirohisa Yano, MD, Junko Sadohara, MD, Toshihiro Matsuo, MD, Yasuhiro Terazaki, MD, Masatoshi Ishibashi, MD, Naofumi Hayabuchi, MD Journal of Thoracic Oncology Volume 2, Issue 11, Pages 1054-1056 (November 2007) DOI: 10.1097/JTO.0b013e318158eee8 Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 [18F]-fluoro-2-deoxy-D-glucose-positron emission tomography transverse axial scan shows a lesion with abnormal FDG-uptake (arrow) in the anterior mediastinum. Journal of Thoracic Oncology 2007 2, 1054-1056DOI: (10.1097/JTO.0b013e318158eee8) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Chest computed tomography scan shows a lesion (arrow) with slight contrast enhancement and with spotty calcification. Journal of Thoracic Oncology 2007 2, 1054-1056DOI: (10.1097/JTO.0b013e318158eee8) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Both T1-weighted (A) and T2-weighted (B) images show a low signal intensity lesion (arrow) with an irregular contour in the anterior mediastinum, and coronal T1-weighted image (C) shows that the low signal intensity lesion (arrow) has an irregular margin and is not encapsulated. Journal of Thoracic Oncology 2007 2, 1054-1056DOI: (10.1097/JTO.0b013e318158eee8) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 A, Cut surface of resected specimen shows a whitish-yellow or brown nodule (arrows) with multiple calcified areas. B and C, Microscopically, the nodule consists of a cholesterol granuloma characterized by the appearance of macrophages, foreign body-type giant cells, cholesterol crystals, and hyalinized collagen fibers. Focal hemorrhage is also present. Hematoxylin and eosin stain; original magnification ×12.5 for B and ×50 for C. Journal of Thoracic Oncology 2007 2, 1054-1056DOI: (10.1097/JTO.0b013e318158eee8) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions