Objective monitoring of nasal patency and nasal physiology in rhinitis

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Presentation transcript:

Objective monitoring of nasal patency and nasal physiology in rhinitis Robert A. Nathan, MD, Ron Eccles, PhD, DSc, Peter H. Howarth, BSc (Hons), DM, FRCP, Sverre K. Steinsvåg, MD, PhD, Alkis Togias, MD Journal of Allergy and Clinical Immunology Volume 115, Issue 3, Pages S442-S459 (March 2005) DOI: 10.1016/j.jaci.2004.12.015 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 The technique of posterior rhinomanometry involves a pressure-sensing tube in the mouth, which detects the changes in pressure in the posterior nares, and a flow head to measure nasal airflow. Journal of Allergy and Clinical Immunology 2005 115, S442-S459DOI: (10.1016/j.jaci.2004.12.015) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Spontaneous changes in left and right nasal resistance recorded in 1 patient with common cold. Reproduced with permission from Acta Oto-Laryngologica.50 Journal of Allergy and Clinical Immunology 2005 115, S442-S459DOI: (10.1016/j.jaci.2004.12.015) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Paired measurements of total nasal resistance measured in 21 patients with common cold. Measurements were made no more than 6 minutes apart on 2 separate rhinomanometers with different staff making the measurements. The shaded and unshaded bars represent separate readings for each patient. The figure shows the repeatability of rhinomanometer measurements. Eccles, unpublished data, 2002. Journal of Allergy and Clinical Immunology 2005 115, S442-S459DOI: (10.1016/j.jaci.2004.12.015) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Changes in nasal volume (upper panel), as measured by acoustic rhinometry, and in NAR (lower panel), as measured by active posterior rhinomanometry, with prostaglandin D2 (PGD2) intranasal challenge in healthy subjects. Howarth, unpublished data, 2003. Journal of Allergy and Clinical Immunology 2005 115, S442-S459DOI: (10.1016/j.jaci.2004.12.015) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions