The NFκB inhibitory peptide, IκBα, prevents human vascular smooth muscle proliferation Craig H Selzman, MD, Brian D Shames, MD, Robert C McIntyre, MD,

Slides:

Advertisements

Similar presentations

Professionalism and the work-life balance Thomas S. Huber, MD, PhD Journal of Vascular Surgery Volume 60, Issue 4, Pages (October 2014) DOI:

Advertisements

Maria B. Sukkar, PhD, Shaoping Xie, PhD, Nadia M

Inhibition of phosphatidylinositol 3-kinase and protein kinase C attenuates extracellular matrix protein-induced vascular smooth muscle cell chemotaxis

Keith B Allen, MD, Carl J Shaar, PhD The Annals of Thoracic Surgery

Cytokine release and neutrophil activation are not prevented by heparin-coated circuits and aprotinin administration Jean-Olivier Defraigne, MD, PhD,

Diseased vein grafts express elevated inflammatory cytokine levels compared with atherosclerotic coronary arteries Jan Felix Christiansen, MD, Dirk Hartwig,

Domain-dependent action of urokinase on smooth muscle cell responses

Immunology and failure of valved allografts in children

Robert J Cerfolio, MD, Cyndi Bass, MSN, Charles R Katholi, PhD

Transforming growth factor-β increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulated kinase mitogen-activated.

Bryan A. Whitson, MD, Blake A

Expression of 11β-hydroxysteroid dehydrogenase 1 and 2 in patients with chronic rhinosinusitis and their possible contribution to local glucocorticoid.

Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism

Atherogenic effects of chlamydia pneumoniae: refuting the innocent bystander hypothesis Craig H Selzman, MD, Mihai G Netea, MD, PhD, Michael A Zimmerman,

P38 Mitogen Activated Protein Kinase Mediates Both Death Signaling and Functional Depression in the Heart Meijing Wang, MD, Ben M. Tsai, MD, Mark W.

Craig H Selzman, MD, Stephanie A Miller, MD, Alden H Harken, MD

Overexpression of mutated IκBα inhibits vascular smooth muscle cell proliferation and intimal hyperplasia formation Brian S Zuckerbraun, MD, Carol A.

Andrew D. Shaw, MB, Ara A. Vaporciyan, MD, Xifeng Wu, MD, Terri M

Invited Commentary The Annals of Thoracic Surgery

CTSNet: a unique educational vehicle

What is the marginal cost for marginal risk in cardiac surgery?

Lipopolysaccharide Stimulation of Human Aortic Valve Interstitial Cells Activates Inflammation and Osteogenesis Ashok N. Babu, MD, Xianzhong Meng, MD,

Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells Qinxue Ding,

Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma Po-Jui Chang, MD, Pankaj K. Bhavsar, PhD,

Michelle C. Ellis, MD, Brian S. Diggs, PhD, John T. Vetto, MD, Paul H

Volume 85, Issue 3, Pages (March 2014)

Surgical intervention criteria for thoracic aortic aneurysms: a study of growth rates and complications Michael A Coady, MD, John A Rizzo, PhD, Graeme.

Daniel R. Meldrum, MD, Brian D

Proteasome Inhibition Attenuates Infarct Size and Preserves Cardiac Function in a Murine Model of Myocardial Ischemia-Reperfusion Injury William E. Stansfield,

Susanne Lison, MD, Michael Spannagl, MD, PhD, Wulf Dietrich, MD, PhD

A simplified technique for closing thoracostomy incisions

Public policy and the practicing physician

Recurrent thoracic outlet syndrome

William T. Mahle, MD, Emilia Matthews, MS, Kirk R. Kanter, MD, Brian E

Origins of the Cardiothoracic Surgery Network (CTSNet)

Who Do You Say You Are? The Annals of Thoracic Surgery

Heparin Reduces Overcirculation-Induced Pulmonary Artery Remodeling Through P38 MAPK in Piglet Gaofeng Zhao, MD, PhD, Jingjing Seng, MD, PhD, John Beagle,

Inhibition of phosphatidylinositol 3-kinase and protein kinase C attenuates extracellular matrix protein-induced vascular smooth muscle cell chemotaxis

Platelet-derived growth factor is a cofactor in the induction of 1α(I) procollagen expression by transforming growth factor β1 in smooth muscle cells

Heparin-induced thrombocytopenia and cardiac surgery

The effects of glucocorticoids on human eosinophils

Coronary surgery without cardiotomy suction and autotransfusion reduces the postoperative systemic inflammatory response Martin Westerberg, MD, Anders.

Nitric oxide inhibition increases matrix metalloproteinase–9 expression by rat aortic smooth muscle cells in vitro Gilbert R. Upchurch, MD, John W. Ford,

Taeseung Lee, MD, Nowokere Esemuede, MD, Bauer E

Smooth muscle cell migration and proliferation are mediated by distinct phases of activation of the intracellular messenger mitogen-activated protein.

Editorial Board, January 2010

The effect of growth factors, cytokines, and extracellular matrix proteins on fibronectin production in human vascular smooth muscle cells Terry L. Kaiura,

C1-esterase inhibitor reduces reperfusion injury after lung transplantation Mirela Scherer, MD, Stefanos Demertzis, MD, PhD, Frank Langer, MD, Anton Moritz,

The Annals of Thoracic Surgery

Anirudh Vinnakota, MS, Robert Stewart, MD, Gosta Pettersson, MD, PhD

Ronald A. Bronicki, MD, Carl L. Backer, MD, Harris P

Angiogenesis and arteriogenesis in limb ischemia

Is there a role for pneumonectomy in pulmonary metastases?1

Beware the malignant jellyfish

Anthony P.C Yim, MD, Song Wan, MD, PhD, Tak Wai Lee, Ahmed A Arifi

Interleukin-1β inhibits PDGF-BB−induced migration by cooperating with PDGF-BB to induce cyclooxygenase-2 expression in baboon aortic smooth muscle cells

Inhibitory kappa B kinase-β is a target for specific nuclear factor kappa B-mediated delayed cardioprotection Nancy C. Moss, MD, Ru-Hang Tang, PhD, Monte.

Robert Lee Replogle, September 30, 1931–May 9, 2016

A ventricular assist device powered by conditioned skeletal muscle

The American Board of Thoracic Surgery: Update

Neal S Goldstein, MD The Annals of Thoracic Surgery

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

The effects of endothelial injury on smooth muscle cell proliferation

Aprotinin in deep hypothermic circulatory arrest

TH2 Cytokine-enhanced and TGF-β-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-γ.

Effects of somatostatin, somatostatin analogs, and endothelial cell somatostatin gene transfer on smooth muscle cell proliferation in vitro Rajabrata.

Platelet-derived growth factor and extracellular matrix proteins provide a synergistic stimulus for human vascular smooth muscle cell migration Peter.

Aortic root replacement versus aortic valve replacement: a case-match study Paul P Urbanski, MD, Matthias Wagner, MD, Michael Zacher, MD, Robert W Hacker,

Prevention of stenosis after vascular reconstruction: Pharmacologic control of intimal hyperplasia—A review Alexander W. Clowes, MD, Michael A. Reidy,

Calpain inhibitors: The aspirin of the 21st century?

Presentation transcript:

The NFκB inhibitory peptide, IκBα, prevents human vascular smooth muscle proliferation Craig H Selzman, MD, Brian D Shames, MD, Robert C McIntyre, MD, Anirban Banerjee, PhD, Alden H Harken, MD The Annals of Thoracic Surgery Volume 67, Issue 5, Pages 1227-1231 (May 1999) DOI: 10.1016/S0003-4975(99)00252-0

Fig 1 Growth factor and cytokine-induced vascular smooth muscle proliferation. VSMCs were incubated in control media (Cont) or increasing concentrations of FGF (A) or TNF (B) for 24 h. Both FGF and TNF induced concentration-dependent VSMC (∗p < 0.002 versus control). The Annals of Thoracic Surgery 1999 67, 1227-1231DOI: (10.1016/S0003-4975(99)00252-0)

Fig 2 Influence of nonspecific and specific NFκB blockade on unstimulated VSMC growth. Dexamethasone (Dex), calpain inhibitor-1 (CI-1), liposomes containing the GST moiety alone (Lipo), and liposomal IκBα (IκBα) had no effect on unstimulated VSMC proliferation. The Annals of Thoracic Surgery 1999 67, 1227-1231DOI: (10.1016/S0003-4975(99)00252-0)

Fig 3 Influence of nonspecific NFκB inhibition on mitogen-stimulated VSMC. FGF (10 ng/mL) and TNF (10 ng/mL) induced VSMC proliferation compared with control (†p < 0.001). Both dexamethasone (Dex) and calpain inhibitor-1 (CI-1) inhibit FGF- and TNF-induced VSMC proliferation (∗p < 0.001, versus [A] FGF and [B] TNF). The Annals of Thoracic Surgery 1999 67, 1227-1231DOI: (10.1016/S0003-4975(99)00252-0)

Fig 4 Influence of specific NFκB blockade with liposomal delivery of IκBα on mitogen-stimulated VSMC. Both FGF (10 ng/mL) and TNF (10 ng/mL) induced VSMC proliferation compared with control (†p < 0.001). Simultaneous incubation with liposome containing the GST moiety alone (Lipo) had no effect on FGF- or TNF-induced proliferation. Liposomal delivery of IκBα (IκBα) inhibited both FGF- and TNF-stimulated VSMC proliferation (∗p < 0.001, versus [A] FGF and [B] TNF). The Annals of Thoracic Surgery 1999 67, 1227-1231DOI: (10.1016/S0003-4975(99)00252-0)