ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. (A,B)

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ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. (A,B) ATPase-stained cross-sections of EDL muscles from NC and ALS-CSF-injected (ALS) rats. Type 1 fibres are lightly stained and type 2 fibres are darkly stained at pH 9.4. Note the altered pattern of type 1 and type 2 fibres in the ALS group compared with the NC group. Rounding, angulation and grouping of type 2 fibres are also seen. Scale bars: 120 μm. (C,D) Electron micrographs showing NC (C) and ALS (D) groups. Rounded (indicated by hash symbol) and angulated fibres (indicated by asterisk) can be seen in the ALS group, suggesting atrophy of the muscle. (E,F) Mean cross-sectional area (CSA) of muscle fibres. Note that there is no alteration in the CSA of type 1 fibres (E), whereas type 2 fibres showed a significant reduction in CSA, in the ALS group compared with the other control groups (F, **P<0.01, NC versus ALS). n=5 in duplicates. Statistical significance was calculated using one-way ANOVA followed by Tukey's post hoc test. Shruthi Shanmukha et al. Dis. Model. Mech. 2018;11:dmm031997 © 2018. Published by The Company of Biologists Ltd