Sleep timing modifies the effect of MTNR1B variant rs10830963 on risk of T2D in MESA (n = 1,513). Sleep timing modifies the effect of MTNR1B variant rs10830963.

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Sleep timing modifies the effect of MTNR1B variant rs10830963 on risk of T2D in MESA (n = 1,513). Sleep timing modifies the effect of MTNR1B variant rs10830963 on risk of T2D in MESA (n = 1,513). The effect of sleep timing on T2D risk is shown by rs10830963 genotype. The rs10830963G T2D risk allele is shown in red. Lines represent the genotype-specific linear regression of rs10830963 × 7-day actigraphy measured at bedtime (A), midpoint (B), and wake time (C) in 1,513 subjects of multiethnic ancestry, adjusted for age, sex, and BMI. Jacqueline M. Lane et al. Diabetes 2016;65:1741-1751 ©2016 by American Diabetes Association