Dual immunosuppression enhances vasomotor injury: Interactive effect between endothelin-1 and nitric oxide bioavailability Danny Ramzy, MD, Laura C.

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Presentation transcript:

Dual immunosuppression enhances vasomotor injury: Interactive effect between endothelin-1 and nitric oxide bioavailability Danny Ramzy, MD, Laura C. Tumiati, BSc, Elissa Tepperman, BSc, Rohit Sheshgiri, BSc, Jessica Jackman, BSc, Mitesh Badiwala, MD, Vivek Rao, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 135, Issue 4, Pages 938-944 (April 2008) DOI: 10.1016/j.jtcvs.2007.09.075 Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, Endothelial-dependent vasodilation in rat TAo. The graph depicts the cumulative dose-response curves to acetylcholine in aortic segments. CyA and CyA + Hcort treatment results in impaired endothelial-dependent vasorelaxation compared with Hcort and control. B, Endothelial-independent vasodilation in rat TAo. The graph depicts the cumulative dose-response curves to SNP in aortic segments. No differences in %Emax were seen between groups. C, Cumulative dose-response curves to ET-1 in aortic segments of treated rats. Both CyA and Hcort increase vasosensitivity to ET-1. Concomitant treatment synergistically increases vessel sensitivity to ET-1. CyA, Cyclosporine A; Hcort, hydrocortisone; ET, endothelin; Con, control; Ach, acetylcholine. The Journal of Thoracic and Cardiovascular Surgery 2008 135, 938-944DOI: (10.1016/j.jtcvs.2007.09.075) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 A, Quantitative Western blot analysis of ETA Rc expression in the TAo. All treatment groups showed increased ETA Rc expression, with the greatest increase observed in the CyA + Hcort group. B, Quantitative Western blot analysis of ETB Rc protein expression in the TAo. No differences were observed between groups. C, Quantitative Western blot analysis of eNOS protein expression in the TAo. Both CyA and Hcort decreased eNOS expression, with CyA + Hcort demonstrating a synergistic reduction. ET, Endothelin; Rc, receptor; Con, control; CyA, cyclosporine A; Hcort, hydrocortisone; eNOS, endothelial nitric oxide synthase. The Journal of Thoracic and Cardiovascular Surgery 2008 135, 938-944DOI: (10.1016/j.jtcvs.2007.09.075) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions