The Clinical Impact of Solid and Micropapillary Patterns in Resected Lung Adenocarcinoma Naoki Yanagawa, MD, PhD, Satoshi Shiono, MD, PhD, Masami Abiko,

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The Clinical Impact of Solid and Micropapillary Patterns in Resected Lung Adenocarcinoma Naoki Yanagawa, MD, PhD, Satoshi Shiono, MD, PhD, Masami Abiko, MD, PhD, Masato Katahira, MD, Mitsumasa Osakabe, MD, PhD, Shin-ya Ogata, MD, PhD Journal of Thoracic Oncology Volume 11, Issue 11, Pages 1976-1983 (November 2016) DOI: 10.1016/j.jtho.2016.06.014 Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 The recurrence-free survival curve (A) and the overall survival curve (B) according to the predominant histopathological patterns in all stages (N = 531). The recurrence-free survival and overall survival differed significantly among the predominant histopathological patterns (p < 0.01 and p < 0.01, respectively). Lepidic means lepidic adenocarcinoma with adenocarcinoma in situ and minimally invasive adenocarcinoma. IMA, invasive mucinous adenocarcinoma. Journal of Thoracic Oncology 2016 11, 1976-1983DOI: (10.1016/j.jtho.2016.06.014) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 The recurrence-free survival curve (A) and the overall survival curve (B) according to the five subgroups in all stages (N = 531). The recurrence-free survival and overall survival differed significantly among the five subgroups (p < 0.01 and p < 0.01, respectively). S–, solid pattern absent; MP –, micropapillary pattern absent; S+ not pre, solid pattern present but not predominant; MP+ not pre, micropapillary pattern present but not predominant; S pre, solid predominant pattern; MP pre, micropapillary predominant pattern. Journal of Thoracic Oncology 2016 11, 1976-1983DOI: (10.1016/j.jtho.2016.06.014) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

Figure 3 The recurrence-free survival curve (A) and the overall survival curve (B) according to the five subgroups in patients with stage I disease (N = 420). The recurrence-free survival and overall survival differed significantly among the five subgroups (p < 0.01 and p < 0.01, respectively). S–, solid pattern absent; MP –, micropapillary pattern absent; S+ not pre, solid pattern present but not predominant; MP+ not pre, micropapillary pattern present but not predominant; S pre, solid predominant pattern; MP pre, micropapillary predominant pattern. Journal of Thoracic Oncology 2016 11, 1976-1983DOI: (10.1016/j.jtho.2016.06.014) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions