Volume 138, Issue 5, Pages (November 2010)

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Volume 138, Issue 5, Pages 1140-1147 (November 2010) Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD Camille Doe, MSc, Mona Bafadhel, MBChB, Salman Siddiqui, PhD, Dhananjay Desai, MBBS, Vijay Mistry, BSc, Paul Rugman, PhD, Margaret McCormick, BSc, Joanne Woods, PhD, Richard May, PhD, Matthew A. Sleeman, PhD, Ian K. Anderson, PhD, Christopher E. Brightling, PhD, FCCP CHEST Volume 138, Issue 5, Pages 1140-1147 (November 2010) DOI: 10.1378/chest.09-3058 Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 1. IL-17A and IL-17F expression in the submucosa in asthma. Representative photomicrographs of bronchial biopsy sections from subjects with severe asthma, illustrating isotype control. A, Goat IgG. B, IL-17A+ cells present in the bronchial submucosa. C, IL-17F+ cells in the submucosa (× 400). IL-17A/F+ cells highlighted by arrows. D, The number of IL-17A+ and E, IL-17F+ cells in the bronchial submucosa of healthy control subjects, subjects with mild to moderate asthma (Global Initiative for Asthma [GINA] 1–3), and subjects with severe asthma (GINA 4–5). P values for across-group comparison by Kruskal-Wallis test and Dunn post hoc test for between-group comparisons are as shown. CHEST 2010 138, 1140-1147DOI: (10.1378/chest.09-3058) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 2. IL-17A and IL-17F expression in the submucosa in COPD. Representative photomicrographs of proximal airway resections from COPD tissue, illustrating isotype control. A, Goat IgG. B, IL-17A+ cells present in the submucosa. C, IL-17F+ cells in the submucosa (× 400). IL-17A/F+ cells highlighted by arrows. D, The number of IL-17A+ and E, IL-17F+ cells in the submucosa of healthy control subjects (never smokers), healthy control subjects (smokers), and subjects with COPD. P values for across-group comparison by Kruskal-Wallis test and Dunn post hoc test for between-group comparisons are as shown. CHEST 2010 138, 1140-1147DOI: (10.1378/chest.09-3058) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 3. Sputum IL-17 in asthma and COPD. A, Sputum IL-17 concentration in asthma and COPD. Horizontal bar represents the median. B, Correlations between sputum IL-17 concentration in subjects with COPD and postbronchodilator FEV1% predicted. C, Correlations between sputum IL-17 concentration in subjects with COPD and FEV1/FVC. CHEST 2010 138, 1140-1147DOI: (10.1378/chest.09-3058) Copyright © 2010 The American College of Chest Physicians Terms and Conditions